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NEW QUESTION: 1
Which of the following statements is true regarding Drug-receptor bonds?
A. Bond formation of between the acetyl group of aspirin and cyclo-oxygenase enzyme is a covalent bond
B. Electrostatic bonds are stronger than covalent bonds
C. Covalent bonds of drugs with receptors are strong and mostly reversible
D. Covalent bonding is much more common than electrostatic bonding in drug-receptor interactions
E. Hydrophobic bonds are weak bonds and they are important in the interactions of highly water soluble drugs with the lipids of cell membranes
Answer: A
Explanation:
Explanation
Drugs mainly interact with the receptors by means of chemical forces or bonds. There are three major types of drug receptor bonds: - Covalent - Electrostatic - Hydrophobic Covalent bonds are very strong bonds and in most of the cases they are irreversible under biologic conditions. For example, the covalent bond between the acetyl group of aspirin and cyclo-oxygenase enzyme (target enzyme present on the platelets) does not breaks easily. The platelet aggregation effect of aspirin lasts long after free acetyl-salicylic acid has disappeared from the blood (about 15 minutes) and it is reversed only by the synthesis of new cyclo-oxygenase enzyme in new platelets which takes a long time. Hence the effect of aspirin is seen after the drug is stopped. Among the drug receptor interactions, electrostatic bond is much more commonly found than covalent bond. The electrostatic bonds vary from relatively strong linkages between permanently charged ionic molecules to weaker hydrogen bonds and very weak induced dipole interactions such as van der Waals force. The electrostatic bonds are weaker than covalent bonds. Hydrophobic bonds are usually very weak bonds and probably important in the interactions of highly lipid soluble drugs with the lipids of cell membranes and perhaps in the interactions of the drugs with the internal walls of receptor "pockets".

NEW QUESTION: 2
Your network contains an Active Directory domain. The domain contains four domain controllers.
You create a new application directory partition.
You need to ensure that the new application directory partition replicates to only three of the domain controllers.
Which tool should you use?
A. Dsdbutil
B. Dsmgmt
C. Active Directory Administrative Center
D. Dsmod
Answer: C

NEW QUESTION: 3
Which of the following report is used for master data load of "Employee" master data object?
Please choose the correct answer.
Response:
A. RCOD_ERP_EMP_EXTRACT
B. COD_ERP_EMP_EXTRACT
C. RHLEINI
D. RHALEINI
Answer: D

NEW QUESTION: 4

A. Option D
B. Option A
C. Option B
D. Option C
E. Option E
Answer: C
Explanation:
The AuditLogAgeLimit parameter of the Set-Mailbox cmdlet allows you to stipulate how long audit logs for a mailbox are retained. Logs older than the specified period are removed. The default value is 90 days.
To meet the requirements in this question, we need to configure a litigation hold on the mailbox.
Place a mailbox on Litigation Hold to preserve all mailbox content, including deleted items and original versions of modified items. When you place a user' mailbox on Litigation Hold, content in the user's archive mailbox (if it's enabled1 is also placed on hold. Deleted and modified items are preserved for a specified period, or until you remove the mailbox from Litigation Hold.
To place a mailbox on litigation hold, we use the Set-Mailbox cmdlet. For example:
Set-Mailbox [email protected] -LitigationHoldEnabled $true -LitigationHoldDuration 60
References:
https://technet.microsoft.com/en-IN/library/bb123981(v=exchg.1501?f=255&MSPPError=-2147217396